The team constructed a catalogue of the proteins found in these systems, taking careful note of how their levels changed as the ages of the donors increased. The researchers compared their findings to a database of diseases and their associated genes, and found that expressions of 48 disease-related proteins increased with age.
These included cardiovascular conditions, tissue fibrosis, fatty liver disease, and liver-related tumors.
The most stark changes occurred between the ages of 45 and 55, the researchers found. It's at this point that many tissues undergo substantial proteomic remodeling, with the most marked changes occurring in the aorta – demonstrating a strong susceptibility to aging. The pancreas and spleen also showed sustained change.
SOMEWHAT PUZZLING BECAUSE ANOTHER STUDY SHOWED BETWEEN THE AGES OF 78 AND 80 THERE WAS A SIGNIFICANCE INCREASE OF AGE RELATED PROBLEMS....I AM IN THE TARGET ZONE... AT 72 i WAS DOING GOOD FOR MY AGE, THEN A BRICK WALL AND I FIND AGING IS NOT FOR SISSIES.....IT FRIGGIN HURTS.... ACHEY BONES, BACK, NECK, SHOULDERS....AND I AM NOT A COUCH POTATO...TOO HYPER.
I just lost the hearing in my right ear about 6 weeks ago and it's not coming back, even with a hearing aid. Part of it could be two years of heavy chemo that damaged one of my auditory nerves, but I suspect that all the years of using air hammers and other load machinery probably contributed to most of the damage. I also have Lynch Syndrome, which means I'll likely gat a fourth cancer at some point. Most of my aches and pains could probably be traced back to my activities and environments of the past.
However, at 62 I still run circles around every younger employee in our restaurant (I average about 5 miles a day unless I'm cooking).
The left is angry because they are now being judged by the content of their character and not by the color of their skin.
