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The paper (pay-per-access): http://stm.sciencemag.org/content/3/70/70ra13.abstractLife can be treacherous for Ecuadorians with Laron syndrome, a rare type of dwarfism. As children, they are vulnerable infectious diseases. As adults, they are prone to fatal accidents, such as falls on stairs that aren't sized for their short legs. But a new study shows that these people, who carry a genetic defect that prevents them from responding to growth hormone, are almost exempt from cancer and diabetes. The paper solidifies a link researchers have long suspected from animal studies and suggests that dialing down the growth-controlling molecular pathways might protect healthy adults from these diseases.
The scientists analyzed medical information for the 99 subjects Guevara-Aguirre has been tracking, for another 53 Laron patients who died before 1988, and for more than 1600 relatives who didn't have the condition. Only one of the Laron subjects developed cancer, an ovarian tumor that didn't recur after chemotherapy. By contrast, cancer killed 20% of the normal-sized relatives. The Laron syndrome individuals were also free of type 2 diabetes, the cause of death for 5% of their taller kin, the team reported in the 16 February issue of Science Translational Medicine.
The diabetes result was surprising because Laron syndrome often causes obesity, a risk factor for diabetes. But the researchers found that the subjects, like the minimice, had lower blood insulin levels and much higher sensitivity to the hormone than did controls. Scientists haven't worked out exactly how GH prompts diabetes. But Longo and colleagues did identify a possible mechanism for the Laron subjects' cancer resistance. GH rouses another hormone, insulin-like growth factor-1 (IGF-1), and researchers think that both molecules promote cancer. Adding IGF-1 to the serum from the Laron group cut the amount of cell suicide to control levels, possibly increasing cancer susceptibility.
Black bears hibernate for 5 to 7 months a year and, during this time, do not eat, drink, urinate, or defecate. We measured metabolic rate and body temperature in hibernating black bears and found that they suppress metabolism to 25% of basal rates while regulating body temperature from 30° to 36°C, in multiday cycles. Heart rates were reduced from 55 to as few as 9 beats per minute, with profound sinus arrhythmia. After returning to normal body temperature and emerging from dens, bears maintained a reduced metabolic rate for up to 3 weeks. The pronounced reduction and delayed recovery of metabolic rate in hibernating bears suggest that the majority of metabolic suppression during hibernation is independent of lowered body temperature.
Hibernating black bears kept a curled posture (Fig. 1), similar to that previously described (13), that facilitates heat preservation and water economy. Animals changed position twice a day to once every 2 days, when they stood, occasionally groomed, and rearranged bedding material.
Insights into how hibernating bears achieve and cope with these reductions in energy need and Tb, as well as conservation of muscle (27, 28) and bone mass (29) despite prolonged seasonal inactivity and disuse, could lead to the development of novel clinical therapies.
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Science Chic wrote: This is why money is needed for basic research.
More general, random info:
http://www.sciencemag.org/content/331/6019/906.full
Hibernation in Black Bears: Independence of Metabolic Suppression from Body Temperature
Science 18 February 2011:
Vol. 331 no. 6019 pp. 906-909
DOI: 10.1126/science.1199435Black bears hibernate for 5 to 7 months a year and, during this time, do not eat, drink, urinate, or defecate. We measured metabolic rate and body temperature in hibernating black bears and found that they suppress metabolism to 25% of basal rates while regulating body temperature from 30° to 36°C, in multiday cycles. Heart rates were reduced from 55 to as few as 9 beats per minute, with profound sinus arrhythmia. After returning to normal body temperature and emerging from dens, bears maintained a reduced metabolic rate for up to 3 weeks. The pronounced reduction and delayed recovery of metabolic rate in hibernating bears suggest that the majority of metabolic suppression during hibernation is independent of lowered body temperature.
Hibernating black bears kept a curled posture (Fig. 1), similar to that previously described (13), that facilitates heat preservation and water economy. Animals changed position twice a day to once every 2 days, when they stood, occasionally groomed, and rearranged bedding material.
Insights into how hibernating bears achieve and cope with these reductions in energy need and Tb, as well as conservation of muscle (27, 28) and bone mass (29) despite prolonged seasonal inactivity and disuse, could lead to the development of novel clinical therapies.
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Throughout the rest of that week, just months after the end of the Second World War, 16,695 babies were born in England, Scotland and Wales. Health visitors carefully recorded the weights of the vast majority on a four-page questionnaire, along with countless other details including the father's occupation, the number of rooms and occupants (including domestics) in the baby's home and whether the baby was legitimate or illegitimate. Over subsequent years, the information files on more than 5,000 of these children thickened, then bulged. Throughout their school years and young adulthood and on into middle age, researchers weighed, measured, prodded, scanned and quizzed the group's bodies and minds in almost every way imaginable.
This week, the group has much to celebrate. They are turning 65, the age at which many in the United Kingdom retire and, as such, a milestone in British life. They will also celebrate being part of the longest-running birth-cohort study in the world. These ordinary men and women are now some of the best-studied people on the planet. And this makes them some of the most scientifically valuable, because it has allowed researchers to track their health and wealth throughout their lives, and to search for factors that could explain their trajectories.
At least one study has hinted at the power of the cohort's life-course data combined with genetics. Last year, Rebecca Hardy, a statistician with the survey, published a study of two hot genes called FTO and MC4R, variants of which have been identified as risk factors for obesity6. When she analysed DNA collected from the cohort in 1999, she found that the association of those variants with body mass index increased in early adult life, then weakened as the cohort grew older. Perhaps, Hardy speculates, any effects of the genes on appetite or fat storage were overwhelmed by that onslaught of fat-promoting influences in the 1980s, a possibility that might become clearer when she tests a further panel of obesity-linked genes.
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Link on Sapce.comAir Force's X-37B Space Plane Launching on Secret Mission Friday
The U.S. Air Force's secretive X-37B space plane is poised to launch on its second mission Friday (March 4), though what exactly it will be doing once it leaves the ground remains a mystery.
The robotic X-37B mini-shuttle is slated to lift off from Cape Canaveral, Fla., on Friday atop an Atlas 5 rocket, weather permitting. Its launch window opens at 3:39 p.m. EST (2039 GMT), according to the launch provider United Launch Alliance, which is overseeing the flight.
This will mark the second space mission for the Air Force's X-37B space plane program — but the first for this particular plane. It is the second X-37B spacecraft built for the Air Force by Boeing and carries the name Orbital Test Vehicle 2, or OTV-2.
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