Hydroxychloroquine WILL Save US

This can be found at
www.ncbi.nlm.nih.gov/pmc/articles/PMC7151271/#appsec1

Unfortunately the EDIT tab is not on my screen with this version of MYM.  Otherwise I would have added it to the above citation.

The following is a concise description of how one prescribes HCQ therapy.
From: jamanetwork.com   4/29/30, 

April 30, 2020"First Do No Harm" is impossible when doing nothing holds the possibility doing more harm.Anthony Cusano, MD | Waterbury Health "Medicine is a science of uncertainty and an art of probability".  

"First, do no harm" was a wise missive when much of what physicians did had significant uncertainty and low probability of success. Its thoughtless application to a disease with a high probability of severe adverse outcomes does not follow any useful tradition of medical tradition.

Hydroxychloroquine is the fifth most widely prescribed drug in the world with exceedingly rare adverse effects documented. The prolonged QT interval it can cause has rarely been associated with sudden death, though it certainly warrants close attention when using the medication.  

A better way to approach this clinical dilemma is to review the benefits, risks, alternatives, and unknowns, and invite a shared decision by the patient or their family. That allows them to chose the potential harm of unclear action or the potential harm of no action at all.

Front Line COVID-19 Critical Care Consortium urges immediate adoption of early intervention protocol to prevent mortality and reduce the need for ventilators from COVID-19 disease.

Another thoughtful  presentation of rx of Covid-19 patients.  well worth reading.
The protocol espoused includes:
      THERAPEUTIC PROTOCOL TO CONTROL INFLAMMATION AND EXCESS CLOTTINGHigh Dose Intravenous Ascorbic Acid3 grams every 6 hourscontinue for a total of 7 days or until dischargedFull Dose Low Molecular Weight Heparin1 mg/kg subcutaneous injection every 12 hourscontinue until discharged  Intravenous Methylprednisolone60mgonceadaycontinue for 7 days, thenswitch to oral prednisone, taper over 6 daysOral Hydroxychloroquine400 mg every 12 hours for one dayswitch to 200 mg every 12 hours for a total of 4 daysAn interesting comment is found in powerlineblog.com 5/2/20

POSTED ON MAY 2, 2020 BY JOHN HINDERAKER IN CORONAVIRUSHOW TREATABLE IS COVID-19?The Wuhan epidemic has exposed a rift between the academic medicine types who dominate the Centers for Disease Control and similar agencies in the states and practicing physicians who are actually treating COVID patients. The former have generally been unhelpful; CDC in particular has performed poorly. Meanwhile, doctors on the front line have developed effective treatment regimens for the virus–regimens which apparently would save many lives if they were broadly publicized and implemented.A group of critical care physicians representing the University of Tennessee, the University of Wisconsin, Eastern Virginia Medical School, the University of Texas and a number of other institutions have formed the Front Line COVID-19 Critical Care Consortium and released a bulletin setting out a recommended treatment protocol. The protocol is based largely on the fact that it is not the virus, but the body’s reaction to the virus, that kills patients:

A LARGE SCALE HUMAN CHALLENGE needs to be implemented.....with proper protocol in place, and extensive
testing needs to be implemented......THAT testing is woefully lacking.

The voluntary "human " host ... in the THOUSANDS...is the only way we will be able to understand the virus and
the poss.rx cure...since there is MORE THAN ONE poss drug.....which is best....AGAIN dosing is a problem.....after
all ONE SIZE FITS ALL is not applicable in medicine....(until recently, that was how medicine was dispensed....until
dna sequencing  came into being.)

"A LARGE SCALE HUMAN CHALLENGE needs to be implemented.....with proper protocol in place,"

Please explain, i don't want to make any assumptions as to what you have  in mend.

ramage wrote: "A LARGE SCALE HUMAN CHALLENGE needs to be implemented.....with proper protocol in place,"

Please explain, i don't want to make any assumptions as to what you have  in mend.

THIS ties into First DO NO HARM comment from U........

www.who.int/biologicals/expert_committee..._Trials_IK_final.pdf

The citation that you proffered relates to human challenge trials for vaccines.  It has nothing to do with how patients are being treated at this  time.  
    You want to deflect from actual treatment into the world of today.
   As per the article I cited, Hydoroxychloroquine is an integral part of the therapy for patients hospitalized because of Covid-19.  Do you have a problem with that?  If so what protocol would you suggest?

ramage wrote: The following is a concise description of how one prescribes HCQ therapy.
From: jamanetwork.com   4/29/30, 

April 30, 2020"First Do No Harm" is impossible when doing nothing holds the possibility doing more harm.Anthony Cusano, MD | Waterbury Health "Medicine is a science of uncertainty and an art of probability".  

"First, do no harm" was a wise missive when much of what physicians did had significant uncertainty and low probability of success. Its thoughtless application to a disease with a high probability of severe adverse outcomes does not follow any useful tradition of medical tradition.

Hydroxychloroquine is the fifth most widely prescribed drug in the world with exceedingly rare adverse effects documented. The prolonged QT interval it can cause has rarely been associated with sudden death, though it certainly warrants close attention when using the medication.  

A better way to approach this clinical dilemma is to review the benefits, risks, alternatives, and unknowns, and invite a shared decision by the patient or their family. That allows them to chose the potential harm of unclear action or the potential harm of no action at all.

''CERTAINLY WARRANTS CLOSE ATTENTION WHEN USING THE MED.''.........WE HAVE TWO CHOICES THAT WILL
EXPEDITE THE LEARNING CURVE OF RX AND VIRUS......HERD IMMUNITY(WHICH WILL TAKE A COUPLE OF YEARS
TO ACHIEVE 60 PERCENT OR SO......OR HUMAN CHALLENGE...WHICH KEYS INTO INFORMED CONSENT ON
A LARGE SCALE.. to treat on an individual scale,is tedious and time consuming and the one thing that is paramount
isTIME......jmo.......the king is NOT going to provide an adequate platform for resolution to this fubar....it is up to heroic
humans and scientists to accomplish that......the concern I have is FDA fast tracking said drugs,approving them and
THEN months later recalling because of serious side effects/problems.....THAT is currently the M.O. of meds on
the market AND medical devices.....HUMAN CHALLENGE IS A SOLUTION... JMO

There is a lot of  jmo ( curiously you do not capitalize jmo) in your response.  I am trying very hard to understand your posting.  
   Let me try this, you  want to continue current restrictions or increase them until  a vaccine os found?  You want to have "more testing" but won't tell us what constitutes more?  You  refuse to acknowledge HCQ therapy because the drug may have side effects, ignoring the fact that is  a drug that has been prescribed for more than 50 years to untold millions of patients and that multiple critical care physicians are prescribing it? 
    As another commentator on MTM  said, and I paraphrase, you can stay in your basement but the  rest of the US is moving along.  

Short CommunicationCan post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in long-term care hospitals?Author links open overlay panelSun HeeLeea1HyunjinSonb1Kyong RanPeckcShow morehttps://doi.org/10.1016/j.ijantimicag.2020.105988Get rights and contentHighlights•In the context of the ongoing COVID-19 pandemic, management of exposure events is a concern.•There was a large COVID-19 exposure event at a long-term care hospital in Korea.•Post-exposure prophylaxis using hydroxychloroquine was provided to 211 individuals.•Disease development was successfully prevented without severe adverse events.


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