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Hydroxychloroquine WILL Save US
- ScienceChic
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16 Apr 2020 08:22 - 16 Apr 2020 08:25 #81
by ScienceChic
"Now, more than ever, the illusions of division threaten our very existence. We all know the truth: more connects us than separates us. But in times of crisis the wise build bridges, while the foolish build barriers. We must find a way to look after one another as if we were one single tribe.” -King T'Challa, Black Panther
The truth is incontrovertible. Malice may attack it. ignorance may deride it, but in the end, there it is. ~Winston Churchill
Replied by ScienceChic on topic Hydroxychloroquine WILL Save US
Want studies? Go to the
PubMed database
and do a search for Hydroxychloroquine + COVID (or coronavirus), new papers are being added every day (way cooler than back when I started in science and you had to wait until the hard copy of the journal came out, which would seriously hamper rapid responses to pandemics such as this). Here's the first page of those results when I just did it:
Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know.
Ann Intern Med. 2020 Mar 31 : M20-1334.
Published online 2020 Mar 31. doi: 10.7326/M20-1334
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
Int J Antimicrob Agents. 2020 Mar 20 : 105949.
doi: 10.1016/j.ijantimicag.2020.105949 [Epub ahead of print]
Chloroquine and hydroxychloroquine in covid-19.
BMJ 2020; 369 doi: doi.org/10.1136/bmj.m1432 (Published 08 April 2020) Cite this as: BMJ 2020;369:m1432
Hydroxychloroquine use during the COVID-19 pandemic 2020.
Australian Journal of General Practice
PMID: 32294807 DOI: 10.31128/AJGP-COVID-08
ANTIVIRAL TREATMENT OF COVID-19.
Turk J Med Sci. 2020 Apr 15. doi: 10.3906/sag-2004-145. [Epub ahead of print]
Hyperglycemia, Hydroxychloroquine, and the COVID-19 Epidemic.
J Med Virol. 2020 Apr 15. doi: 10.1002/jmv.25887. [Epub ahead of print]
Target Virus or Target Ourselves for COVID-19 Drugs Discovery?-Lessons learned from anti-influenzas virus therapies.
Med Drug Discov. 2020 Apr 13:100037. doi: 10.1016/j.medidd.2020.100037. [Epub ahead of print]
Meeting the Potential Emergency Global Drug Supply Challenge of Hydroxychloroquine for COVID-19.
Medicine in Drug Discovery. 2020 Apr 9 : 100036.
doi: 10.1016/j.medidd.2020.100036 [Epub ahead of print]
Coalition: Advocacy for prospective clinical trials to test the post-exposure potential of hydroxychloroquine against COVID-19.
One Health. 2020 Apr 4 : 100131.
doi: 10.1016/j.onehlt.2020.100131 [Epub ahead of print]
COVID-19: A Brief Overview of the Discovery Clinical Trial.
Pharmaceuticals (Basel). 2020 Apr 10;13(4). pii: E65. doi: 10.3390/ph13040065.
A Review of SARS-CoV-2 and the Ongoing Clinical Trials.
Int J Mol Sci. 2020 Apr 10;21(7). pii: E2657. doi: 10.3390/ijms21072657.
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
Travel Med Infect Dis. 2020 Apr 11:101663. doi: 10.1016/j.tmaid.2020.101663. [Epub ahead of print]
Optimizing hydroxychloroquine dosing for patients with COVID-19: An integrative modeling approach for effective drug repurposing.
Clin Pharmacol Ther. 2020 Apr 14. doi: 10.1002/cpt.1856. [Epub ahead of print]
Coronavirus Disease 2019 Treatment: A Review of Early and Emerging Options.
Open Forum Infect Dis. 2020 Mar 23;7(4):ofaa105. doi: 10.1093/ofid/ofaa105. eCollection 2020 Apr. Review. PMID: 32284951
Hydroxychloroquine and ivermectin: a synergistic combination for COVID-19 chemoprophylaxis and/or treatment?
J Am Acad Dermatol. 2020 Apr 10. pii: S0190-9622(20)30557-0. doi: 10.1016/j.jaad.2020.04.017. [Epub ahead of print]
Does Hydroxychloroquine Combat COVID-19? A Timeline of Evidence.
J Am Acad Dermatol. 2020 Apr 10. pii: S0190-9622(20)30607-1. doi: 10.1016/j.jaad.2020.04.031. [Epub ahead of print]
Early Impact of COVID-19 on Transplant Center Practices and Policies in the United States.
Am J Transplant. 2020 Apr 13. doi: 10.1111/ajt.15915. [Epub ahead of print]
Cardiovascular Considerations in Treating Patients with Coronavirus (COVID-19).
J Cardiovasc Pharmacol. 2020 Apr 2. doi: 10.1097/FJC.0000000000000836. [Epub ahead of print]
Update on use of chloroquine/hydroxychloroquine to treat coronavirus disease 2019 (COVID-19).
Biosci Trends. 2020 Apr 13. doi: 10.5582/bst.2020.03072. [Epub ahead of print]
Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review.
J Toxicol Environ Health B Crit Rev. 2020 Apr 12:1-5. doi: 10.1080/10937404.2020.1752340. [Epub ahead of print]
G6PD and chloroquine: selecting the treatment against SARS-CoV-2?
J Cell Mol Med. 2020 Apr 12. doi: 10.1111/jcmm.15312. [Epub ahead of print]
Delayed Initiation of Remdesivir in a COVID-19 Positive Patient.
Pharmacotherapy. 2020 Apr 13. doi: 10.1002/phar.2403. [Epub ahead of print]
Reviews of the published literature to date are especially helpful for finding more, and seeing what the experts are finding from a 30,000' view:
A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in Coronavirus Disease-19 (COVID-19).
Int J Rheum Dis. 2020 Apr 13. doi: 10.1111/1756-185X.13842. [Epub ahead of print]
My earlier post in this topic, which lists a few:
Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know.
Ann Intern Med. 2020 Mar 31 : M20-1334.
Published online 2020 Mar 31. doi: 10.7326/M20-1334
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
Int J Antimicrob Agents. 2020 Mar 20 : 105949.
doi: 10.1016/j.ijantimicag.2020.105949 [Epub ahead of print]
Chloroquine and hydroxychloroquine in covid-19.
BMJ 2020; 369 doi: doi.org/10.1136/bmj.m1432 (Published 08 April 2020) Cite this as: BMJ 2020;369:m1432
Hydroxychloroquine use during the COVID-19 pandemic 2020.
Australian Journal of General Practice
PMID: 32294807 DOI: 10.31128/AJGP-COVID-08
ANTIVIRAL TREATMENT OF COVID-19.
Turk J Med Sci. 2020 Apr 15. doi: 10.3906/sag-2004-145. [Epub ahead of print]
Hyperglycemia, Hydroxychloroquine, and the COVID-19 Epidemic.
J Med Virol. 2020 Apr 15. doi: 10.1002/jmv.25887. [Epub ahead of print]
Target Virus or Target Ourselves for COVID-19 Drugs Discovery?-Lessons learned from anti-influenzas virus therapies.
Med Drug Discov. 2020 Apr 13:100037. doi: 10.1016/j.medidd.2020.100037. [Epub ahead of print]
Meeting the Potential Emergency Global Drug Supply Challenge of Hydroxychloroquine for COVID-19.
Medicine in Drug Discovery. 2020 Apr 9 : 100036.
doi: 10.1016/j.medidd.2020.100036 [Epub ahead of print]
Coalition: Advocacy for prospective clinical trials to test the post-exposure potential of hydroxychloroquine against COVID-19.
One Health. 2020 Apr 4 : 100131.
doi: 10.1016/j.onehlt.2020.100131 [Epub ahead of print]
COVID-19: A Brief Overview of the Discovery Clinical Trial.
Pharmaceuticals (Basel). 2020 Apr 10;13(4). pii: E65. doi: 10.3390/ph13040065.
A Review of SARS-CoV-2 and the Ongoing Clinical Trials.
Int J Mol Sci. 2020 Apr 10;21(7). pii: E2657. doi: 10.3390/ijms21072657.
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study.
Travel Med Infect Dis. 2020 Apr 11:101663. doi: 10.1016/j.tmaid.2020.101663. [Epub ahead of print]
Optimizing hydroxychloroquine dosing for patients with COVID-19: An integrative modeling approach for effective drug repurposing.
Clin Pharmacol Ther. 2020 Apr 14. doi: 10.1002/cpt.1856. [Epub ahead of print]
Coronavirus Disease 2019 Treatment: A Review of Early and Emerging Options.
Open Forum Infect Dis. 2020 Mar 23;7(4):ofaa105. doi: 10.1093/ofid/ofaa105. eCollection 2020 Apr. Review. PMID: 32284951
Hydroxychloroquine and ivermectin: a synergistic combination for COVID-19 chemoprophylaxis and/or treatment?
J Am Acad Dermatol. 2020 Apr 10. pii: S0190-9622(20)30557-0. doi: 10.1016/j.jaad.2020.04.017. [Epub ahead of print]
Does Hydroxychloroquine Combat COVID-19? A Timeline of Evidence.
J Am Acad Dermatol. 2020 Apr 10. pii: S0190-9622(20)30607-1. doi: 10.1016/j.jaad.2020.04.031. [Epub ahead of print]
Early Impact of COVID-19 on Transplant Center Practices and Policies in the United States.
Am J Transplant. 2020 Apr 13. doi: 10.1111/ajt.15915. [Epub ahead of print]
Cardiovascular Considerations in Treating Patients with Coronavirus (COVID-19).
J Cardiovasc Pharmacol. 2020 Apr 2. doi: 10.1097/FJC.0000000000000836. [Epub ahead of print]
Update on use of chloroquine/hydroxychloroquine to treat coronavirus disease 2019 (COVID-19).
Biosci Trends. 2020 Apr 13. doi: 10.5582/bst.2020.03072. [Epub ahead of print]
Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review.
J Toxicol Environ Health B Crit Rev. 2020 Apr 12:1-5. doi: 10.1080/10937404.2020.1752340. [Epub ahead of print]
G6PD and chloroquine: selecting the treatment against SARS-CoV-2?
J Cell Mol Med. 2020 Apr 12. doi: 10.1111/jcmm.15312. [Epub ahead of print]
Delayed Initiation of Remdesivir in a COVID-19 Positive Patient.
Pharmacotherapy. 2020 Apr 13. doi: 10.1002/phar.2403. [Epub ahead of print]
Reviews of the published literature to date are especially helpful for finding more, and seeing what the experts are finding from a 30,000' view:
A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in Coronavirus Disease-19 (COVID-19).
Int J Rheum Dis. 2020 Apr 13. doi: 10.1111/1756-185X.13842. [Epub ahead of print]
Numbers 21-60 of results: PubMed Search for Hydroxychloroquine + COVIDMETHODS:
PubMed, EMBASE, ClinicalTrials.gov, ICTRP, and Cochrane Library databases were searched for studies that evaluated the prophylactic role of CQ or HCQ on SARS-CoV-2 (pre-clinical studies) or COVID-19 (clinical studies) until 30 March 2020. The available literature was critically appraised.
RESULTS:
A total of 45 articles were screened and five (three in vitro pre-clinical studies and two clinical opinions) were included. The pre-clinical studies showed the prophylactic effects of CQ and HCQ against SARS-CoV-2. On the other hand, the clinical opinions advocated the prophylactic use of CQ and HCQ against COVID-19. However, no original clinical studies on the prophylactic role of CQ or HCQ on COVID-19 were available.
CONCLUSION:
Although pre-clinical results are promising, till date, there is dearth of evidence to support the efficacy of CQ or HCQ in preventing COVID-19. Considering potential safety issues and the likelihood of imparting a false sense of security, prophylaxis with CQ or HCQ against COVID-19 needs to be thoroughly evaluated in observational studies or high quality randomized controlled studies.
My earlier post in this topic, which lists a few:
ScienceChic wrote: The Latest Hydroxychloroquine Data, As of April 11
By Derek Lowe, Science Translational Medicine Blog | 11 April, 2020
Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. All content is Derek’s own, and he does not in any way speak for his employer.We have new data on hydroxychloroquine therapy to discuss. The numbers will not clear anything up.
"Now, more than ever, the illusions of division threaten our very existence. We all know the truth: more connects us than separates us. But in times of crisis the wise build bridges, while the foolish build barriers. We must find a way to look after one another as if we were one single tribe.” -King T'Challa, Black Panther
The truth is incontrovertible. Malice may attack it. ignorance may deride it, but in the end, there it is. ~Winston Churchill
Last edit: 16 Apr 2020 08:25 by ScienceChic.
The following user(s) said Thank You: driver8
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- homeagain
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- Mountain Legend
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16 Apr 2020 08:49 #82
by homeagain
Replied by homeagain on topic Hydroxychloroquine WILL Save US
www.ncbi.nlm.nih.gov/pmc/articles/PMC7138336/
SHORTAGES because of over promised data.....the link is a layman's guide to the issue.THANKS
SC......
SHORTAGES because of over promised data.....the link is a layman's guide to the issue.THANKS
SC......
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- ramage
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16 Apr 2020 08:56 #83
by ramage
Replied by ramage on topic Hydroxychloroquine WILL Save US
SC,
I read Derek Lowe's article earlier this week. As an organic chemist (his training) he is disconcerted by the fact that Raoult's report did not have a control group. In the comments, it was noted that Raoult said
11 April, 2020 at 10:06 am
The French Dr. does not use control groups because he says it is not ethical to kill people.
Derek Lowe says:
11 April, 2020 at 10:16 am
That is indeed his rationalization.
Sorry, but I don't live in Lowe's laboratory. Raoult dealt with sick patients. That is not the time to obtain informed consent for a double blinded drug vs. placebo.
Overall, I enjoyed his article.
We can discuss this article in a separate thread if you wish. Particularly his presentation of the multi-site study of the use of HCQ in the treatment of rheumatoid arthritis from which the following conclusion is reached. "Short-term hydroxychloroquine treatment is safe, but addition of azithromycin may induce heart failure and cardiovascular mortality, potentially due to synergistic effects on QT length. We call for caution if such combination is to be used in the management of Covid-19."
I read Derek Lowe's article earlier this week. As an organic chemist (his training) he is disconcerted by the fact that Raoult's report did not have a control group. In the comments, it was noted that Raoult said
11 April, 2020 at 10:06 am
The French Dr. does not use control groups because he says it is not ethical to kill people.
Derek Lowe says:
11 April, 2020 at 10:16 am
That is indeed his rationalization.
Sorry, but I don't live in Lowe's laboratory. Raoult dealt with sick patients. That is not the time to obtain informed consent for a double blinded drug vs. placebo.
Overall, I enjoyed his article.
We can discuss this article in a separate thread if you wish. Particularly his presentation of the multi-site study of the use of HCQ in the treatment of rheumatoid arthritis from which the following conclusion is reached. "Short-term hydroxychloroquine treatment is safe, but addition of azithromycin may induce heart failure and cardiovascular mortality, potentially due to synergistic effects on QT length. We call for caution if such combination is to be used in the management of Covid-19."
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23 Apr 2020 07:02 #84
by homeagain
Replied by homeagain on topic Hydroxychloroquine WILL Save US
BUMP......so-o-o. what was known for a very long time.....the king's claim, just like everything
else, was erroneous. NOW he is moving on to another lie,(pick any topic)....his mouth is a
dangerous weapon....watch what happens....AS STATES UNDO the proven protocol for
this disease....opening beaches,natl' forests, and other scenarios that will mingle masses of
people....YOU AIN'T SEEN NOTHIN YET.
else, was erroneous. NOW he is moving on to another lie,(pick any topic)....his mouth is a
dangerous weapon....watch what happens....AS STATES UNDO the proven protocol for
this disease....opening beaches,natl' forests, and other scenarios that will mingle masses of
people....YOU AIN'T SEEN NOTHIN YET.
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- ramage
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24 Apr 2020 17:27 #85
by ramage
Replied by ramage on topic Hydroxychloroquine WILL Save US
Another good reason to take HCQ/AZ, the CIA recommends against it.
According to the Washington Post, the CIA privately advised its workforce that taking an anti-malarial drug hydroxychloroquine to treat Coronavirus has potentially dangerous side effects, including possible sudden death.
According to the Washington Post, the CIA privately advised its workforce that taking an anti-malarial drug hydroxychloroquine to treat Coronavirus has potentially dangerous side effects, including possible sudden death.
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25 Apr 2020 08:21 #86
by koobookie
I'm confused by your statement. Are you implying that because the CIA is advising not taking this drug that you are for taking this drug?
Replied by koobookie on topic Hydroxychloroquine WILL Save US
ramage wrote: Another good reason to take HCQ/AZ, the CIA recommends against it.
According to the Washington Post, the CIA privately advised its workforce that taking an anti-malarial drug hydroxychloroquine to treat Coronavirus has potentially dangerous side effects, including possible sudden death.
I'm confused by your statement. Are you implying that because the CIA is advising not taking this drug that you are for taking this drug?
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25 Apr 2020 08:50 #87
by ramage
Replied by ramage on topic Hydroxychloroquine WILL Save US
To be clear, if I had signs and symptoms of Covid-19 and tested positive, I would take HCQ/AZ if recommended by my physician. ( The bonus being that the CIA is warning against it.)
By the way would you take HCQ/AZ if you had the above presentation? If not what therapy other than that of the Cuomo family would you consent to?
By the way would you take HCQ/AZ if you had the above presentation? If not what therapy other than that of the Cuomo family would you consent to?
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25 Apr 2020 09:07 #88
by driver8
Do you always try to use veiled anti-guv colloquialism'ish postings and half assed gotcha's that never find their mark? Asking for a friend.....
I actually messaged MY Dr and she would NOT recommend using or even suggesting HCQ/AZ for me or any of her patients. There is still NO actual full scope study that shows any real effectiveness and so far, many of the reports she is seeing is that is causing more harm than good. One of the first lines in a Dr's Hippocratic Oath is "First do no harm". From what I can tell is that you would do anything to try and defend your leaders ignorant positions and statements. It's really amusing to watch you guys twist and turn yourselves into pretzels trying to support your leader. Good luck with that.
Replied by driver8 on topic Hydroxychloroquine WILL Save US
ramage wrote: To be clear, if I had signs and symptoms of Covid-19 and tested positive, I would take HCQ/AZ if recommended by my physician. ( The bonus being that the CIA is warning against it.)
By the way would you take HCQ/AZ if you had the above presentation? If not what therapy other than that of the Cuomo family would you consent to?
Do you always try to use veiled anti-guv colloquialism'ish postings and half assed gotcha's that never find their mark? Asking for a friend.....
I actually messaged MY Dr and she would NOT recommend using or even suggesting HCQ/AZ for me or any of her patients. There is still NO actual full scope study that shows any real effectiveness and so far, many of the reports she is seeing is that is causing more harm than good. One of the first lines in a Dr's Hippocratic Oath is "First do no harm". From what I can tell is that you would do anything to try and defend your leaders ignorant positions and statements. It's really amusing to watch you guys twist and turn yourselves into pretzels trying to support your leader. Good luck with that.
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25 Apr 2020 09:46 #89
by ramage
Replied by ramage on topic Hydroxychloroquine WILL Save US
To not prescribe HCQ/AZ or prescribe it, is a physician's prerogative. That said, what did she say she would do to treat your Covid-19 infection?
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25 Apr 2020 11:40 #90
by koobookie
That was not an answer to my question. Are you saying that you do not trust the CIA to tell their employees the truth about a potential drug cure?
Replied by koobookie on topic Hydroxychloroquine WILL Save US
ramage wrote: To be clear, if I had signs and symptoms of Covid-19 and tested positive, I would take HCQ/AZ if recommended by my physician. ( The bonus being that the CIA is warning against it.)
By the way would you take HCQ/AZ if you had the above presentation? If not what therapy other than that of the Cuomo family would you consent to?
That was not an answer to my question. Are you saying that you do not trust the CIA to tell their employees the truth about a potential drug cure?
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